![]() ![]() IgG3 comprises around 5 to 10% of total IgG and plays a major role in the immune responses against protein or polypeptide antigens.Ĭomprising usually less than 4% of total IgG, IgG4 does not bind to polysaccharides. Among all IgG isotype deficiencies, a deficiency in IgG2 is the most common and is associated with recurring airway/respiratory infections in infants. It comprises 20 to 25% of the main subclass and is the prevalent immune response against carbohydrate/polysaccharide antigens. A deficiency in IgG1 isotype is typically a sign of a hypogammaglobulinemia. It is also involved in opsonization and activation of the complement cascade. It comprises 60 to 65% of the total main subclass IgG, and predominantly responsible for the thymus-mediated immune response against proteins and polypeptide antigens. Subclasses IgG1, IgG2, IgG3, and IgG4 are differentiated on the basis of the size of the hinge region, position of interchain disulfide bonds, and molecular weight. The subclasses also differ in their ability to activate complement.There are four IgG subclasses (IgG1, 2, 3, and 4) in humans, named in order of their abundance in serum (IgG1 being the most abundant). ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |